Woman raising awareness about metastatic breast cancer symptoms
Breast Cancer

What is Metastatic Breast Cancer Symptoms

Breast cancer that has gone outside the breast to other regions of the body is referred to as metastatic breast cancer, also referred to as stage IV breast cancer. Breast cancer is in an advanced stage at this point, necessitating specialized care.

What is Metastatic Breast Cancer?

Metastatic breast cancer is the most advanced stage of breast cancer, where cancerous cells have spread from the breast to other organs in the body, such as the bones, liver, lungs, or brain. Unlike early-stage breast cancer, metastatic breast cancer is considered incurable, but it can be managed with treatment to prolong life and improve quality of life.

Symptoms of Metastatic Breast Cancer

Depending on the organs or tissues that have been impacted by the metastasis, the symptoms of metastatic breast cancer might change. However, there are some common symptoms to be aware of, including:

  • Persistent fatigue and weakness
  • Unexplained weight loss
  • Bone pain or fractures
  • Shortness of breath or chest pain
  • Headaches or seizures
  • Abdominal pain or swelling

Signs of Metastasis in Different Parts of the Body

Metastatic breast cancer can spread to various parts of the body, leading to specific signs and symptoms. Some examples include:

  • Bone metastasis: Bone pain, fractures, or hypercalcemia (high calcium levels)
  • Liver metastasis: Jaundice, abdominal pain, or swelling
  • Lung metastasis: Persistent cough, shortness of breath, or chest pain
  • Brain metastasis: Headaches, seizures, or changes in cognitive function

Diagnosing Metastatic Breast Cancer

Diagnosing metastatic breast cancer typically involves a combination of medical history evaluation, physical examination, and various diagnostic tests. Here’s an overview of the diagnostic process:

  1. Medical History and Physical Examination: The doctor will inquire about your symptoms, medical history, and any risk factors for breast cancer. They will then conduct a physical examination, paying close attention to any signs of breast abnormalities or symptoms of metastases in other parts of the body.
  2. Imaging Tests: Several imaging tests may be used to detect the presence of metastases and assess the extent of the cancer spread. These may include:
    • X-rays: To detect abnormalities in the bones or lungs.
    • Computed Tomography (CT) Scan: Provides detailed cross-sectional images of the body to identify metastases in organs like the lungs, liver, and brain.
    • Magnetic Resonance Imaging (MRI): Offers detailed images of soft tissues, useful for detecting brain metastases or evaluating the extent of cancer in the breast.
    • Bone Scan: Helps identify areas of bone affected by metastatic breast cancer.
  3. Biopsy: If imaging tests suggest the presence of metastatic lesions, a biopsy may be performed to confirm the diagnosis. During a biopsy, a small sample of tissue is removed from the suspected metastatic site and examined under a microscope by a pathologist to determine if cancer cells are present. This helps confirm whether the metastatic lesions originated from breast cancer.
  4. Blood Tests: Blood tests may be conducted to assess levels of certain biomarkers associated with breast cancer, such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). These tests can provide valuable information for determining treatment options.

Treatment Options for Metastatic Breast Cancer

Treatment options for metastatic breast cancer aim to control the spread of cancer, manage symptoms, and improve quality of life. The choice of treatment depends on factors such as the location and extent of metastases, previous treatments, overall health, and individual preferences. Here are some common treatment options:

Systemic Therapy

Systemic therapy aims to treat cancer cells throughout the body. It includes chemotherapy, which uses drugs to kill cancer cells, and hormone therapy, which targets hormone receptor-positive breast cancers. Systemic therapy may also involve targeted therapies that specifically target certain proteins or pathways involved in cancer growth.

Targeted Therapy

Targeted therapies are designed to inhibit specific molecules or pathways involved in cancer development and progression. Examples include HER2-targeted therapies for HER2-positive breast cancers and CDK4/6 inhibitors for hormone receptor-positive breast cancers.

Hormone Therapy

Breast cancers with hormone receptors are treated with hormone therapy. It works by blocking the effects of estrogen or lowering its levels in the body. Hormone therapy can help slow down the growth of cancer cells and manage the disease.


An revolutionary medical strategy known as immunotherapy uses the immune system’s capacity to combat cancer. While not widely used for metastatic breast cancer, ongoing research is exploring the potential of immunotherapy in improving treatment outcomes.

Surgery and Radiation

Radiation treatment and surgery may occasionally be used to treat metastatic breast cancer. Surgery can remove tumors that are creating difficulties or assist relieve symptoms. Targeting certain metastases, including those in the brain or the bones, is possible with radiation treatment.

Managing Metastatic Breast Cancer

Managing metastatic breast cancer involves a comprehensive approach aimed at controlling the spread of cancer, relieving symptoms, and improving quality of life. Here are some strategies for managing metastatic breast cancer:

Palliative Care

The goal of palliative care is to enhance the quality of life for people with metastatic breast cancer. It involves managing symptoms, providing pain relief, and addressing emotional and psychological needs. Palliative care can be integrated alongside curative treatments or as the main approach for advanced-stage cancer.

Emotional and Psychological Support

Emotionally difficult situations might arise from having metastatic breast cancer. Therapy, support groups, or counselling may be helpful for patients and their families to deal with the psychological effects of the illness. In order to treat emotional needs, open communication with loved ones and healthcare professionals is essential.

Lifestyle Modifications

Healthy lifestyle practices can treat metastatic breast cancer and enhance general wellbeing. This include following a balanced diet, exercising often (as directed by healthcare professionals), controlling stress, and obtaining enough relaxation and sleep.


Metastatic breast cancer is a challenging condition that requires comprehensive management. Early detection of symptoms, accurate diagnosis, and personalized treatment approaches are crucial for improving outcomes. Improvements in treatment choices and supportive care can considerably improve the quality of life for those with metastatic breast cancer, even though the illness may not be curable.


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